Document 0093
 DOCN  M9490093
 TI    Retrovirus-induced immunosuppression via blocking of dendritic cell
       migration and down-regulation of adhesion molecules.
 DT    9411
 AU    Gabrilovich DI; Woods GM; Patterson S; Harvey JJ; Knight SC; Antigen
       Presentation Research Group, Clinical Research Centre,; Harrow, U.K.
 SO    Immunology. 1994 May;82(1):82-7. Unique Identifier : AIDSLINE
       MED/94321005
 AB    Dendritic cells (DC) within tissues may acquire and process antigens,
       carry them into lymph nodes and cluster and activate T cells. The
       ability of DC to acquire antigen and to migrate to lymph nodes was
       estimated during murine retroviral infection caused by Rauscher
       leukaemia virus (RLV). A novel mechanism of inducing immunodeficiency
       has now been identified. In mice infected with RLV, DC failed to migrate
       into lymph nodes following exposure of the skin to the contact
       sensitizer, fluorescein isothiocyanate. RLV infection of a proportion of
       DC both in skin and lymph nodes, shown by semi-quantitative polymerase
       chain reaction (PCR) and down-regulation of expression of adhesion
       molecules (CD54 and CD44) on the surface of Langerhans' cells, may
       contribute to the described phenomenon. A failure of DC migration could
       be an important immunosuppressive mechanism of RLV infection in mice and
       we speculate on a similar role for DC in human immunodeficiency virus-1
       (HIV-1) infection in humans.
 DE    Animal  Base Sequence  Cell Adhesion Molecules/ANALYSIS  Cell
       Movement/IMMUNOLOGY  Dendritic Cells/*IMMUNOLOGY  Down-Regulation
       (Physiology)/IMMUNOLOGY  Female  Immune Tolerance/*IMMUNOLOGY
       Langerhans Cells/IMMUNOLOGY  Leukemia, Experimental/*IMMUNOLOGY  Lymph
       Nodes/IMMUNOLOGY  Mice  Mice, Inbred BALB C  Mice, Inbred C57BL
       Molecular Sequence Data  Oligonucleotide Probes/CHEMISTRY  *Rauscher
       Virus  Retroviridae Infections/*IMMUNOLOGY  Support, Non-U.S. Gov't
       Tumor Virus Infections/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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